The objectives of this analysis were to develop a population pharmacokinetics (PK) model of
durvalumab, an anti‐PD‐L1 antibody, and quantify the impact of baseline and time‐varying …

Covariate modeling is an important opportunity for pharmacometrics to influence decision
making in drug development. The stepwise covariate model (SCM) building procedure is the …

Imeglimin is an orally administered first‐in‐class drug to treat type 2 diabetes mellitus
(T2DM) and is mainly excreted unchanged by the kidneys. The present study aimed to …

Aims A new, long‐acting, subcutaneous (SC) formulation of risperidone (RBP‐7000) has
been developed for the treatment of schizophrenia to address issues of non‐adherence …

A randomized, placebo-controlled trial conducted on the northwest border of Thailand
compared malaria chemoprevention with monthly or bimonthly standard 3-day treatment …

Abstract Dr. Reddy's Laboratories rituximab (DRL_RI; Dr. Reddy's Laboratories SA, Basel,
Switzerland) is under development as a rituximab biosimilar. Study RI‐01‐002 (Clinical …

Purpose Glasdegib, an oral inhibitor of the Hedgehog signaling pathway, is approved in the
United States in combination with low-dose cytarabine (LDAC) to treat patients with newly …

Identification of covariates, including biomarkers, spirometry, and diaries/questionnaires,
that predict asthma exacerbations would allow better clinical predictions, shorter phase II …

The pharmacokinetics (PK) of tenecteplase in patients with acute ischemic stroke has not
been extensively studied. This study aimed to describe PK characteristics of tenecteplase in …

The oral route is and will for, a foreseeable future, be the by far most common way of
administering pharmacological substances. This is natural given the convenience that it …