Osteoclasts are derived from mononuclear phagocyte lineage cells and are indispensable
for bone resorption. Recent findings suggest that fetal yolk sac macrophage progenitors give …

Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone
structure is destroyed to the degree that bone becomes fragile and prone to fractures …

Cells sense mechanical cues from the extracellular matrix to regulate cellular behavior and
maintain tissue homeostasis. The nucleus has been implicated as a key mechanosensor …

Radiotherapy, in addition to surgery and systemic chemotherapy, remains the core of the
current clinical management of cancer. Radioresistance is one of the major causes of …

The bone tissue is a dynamic complex that constitutes of several interdependent systems
and is continuously remodeled through the concerted actions of bone cells. Osteoblasts are …

ABSTRACT ATP‐citrate lyase (ACLY), generating most of the nucleocytosolic acetyl
coenzyme A (acetyl‐CoA) for histone acetylation, links cell metabolism to epigenetic …

Bones serve mechanical and defensive functions, as well as regulating the balance of
calcium ions and housing bone marrow.. The qualities of bones do not remain constant …

Melanoma is a type of skin cancer that develops in pigment-producing melanocytes and
often spreads to other parts of the body. Aberrant gene expression has been considered as …

Epigenetic modifications affect cell differentiation via transcriptional regulation. G9a/EHMT2
is an important epigenetic modifier that catalyzes the methylation of histone 3 lysine 9 …

Neutrophil infiltration and phenotypic transformation are believed to contribute to neuronal
damage in ischemic stroke. Emerging evidence suggests that histone deacetylase 2 …