The roles of the amyloid beta monomers in physiological and pathological conditions

TG Schreiner, OD Schreiner, M Adam, BO Popescu - Biomedicines, 2023 - mdpi.com
Amyloid beta peptide is an important biomarker in Alzheimer's disease, with the
amyloidogenic hypothesis as one of the central hypotheses trying to explain this type of …

The key roles of organelles and ferroptosis in Alzheimerʼs disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Journal of …, 2022 - Wiley Online Library
Alzheimerʼs disease (AD), an age‐related neurodegenerative disease, is a striking global
health problem. Ferroptosis is a newly discovered form of cell death characterized by iron …

Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex

JHY Yeung, JL Walby, TH Palpagama… - Brain …, 2021 - Wiley Online Library
Alzheimer's Disease (AD) is the leading form of dementia worldwide. Currently, the
pathological mechanisms underlying AD are not well understood. Although the …

The effect of age and sex on the expression of GABA signaling components in the human hippocampus and entorhinal cortex

J Ethiraj, TH Palpagama, C Turner, B van der Werf… - Scientific reports, 2021 - nature.com
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the nervous
system. The GABA signaling system in the brain is comprised of GABA synthesizing …

Beta-Amyloid (Aβ1-42) Increases the Expression of NKCC1 in the Mouse Hippocampus

P Lam, C Vinnakota, BCF Guzmán, J Newland… - Molecules, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder with an increasing need for
developing disease-modifying treatments as current therapies only provide marginal …

Glutamate Receptor Dysregulation and Platelet Glutamate Dynamics in Alzheimer's and Parkinson's Diseases: Insights into Current Medications

D Gautam, UP Naik, MU Naik, SK Yadav… - Biomolecules, 2023 - mdpi.com
Two of the most prevalent neurodegenerative disorders (NDDs), Alzheimer's disease (AD)
and Parkinson's disease (PD), present significant challenges to healthcare systems …

[HTML][HTML] The interplay between beta-amyloid 1–42 (Aβ1–42)-induced hippocampal inflammatory response, p-tau, vascular pathology, and their synergistic …

BCF Guzmán, TE Chaffey, TH Palpagama… - Frontiers in Molecular …, 2020 - ncbi.nlm.nih.gov
Abstract Alzheimer's disease (AD), the most common chronic neurodegenerative disorder,
has complex neuropathology. The principal neuropathological hallmarks of the disease are …

EAAT2 expression in the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus in Alzheimer's disease

JHY Yeung, TH Palpagama, OWG Wood… - Frontiers in Cellular …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neuropathological disorder characterized by the presence and
accumulation of amyloid-beta plaques and neurofibrillary tangles. Glutamate dysregulation …

The Interplay Between Beta-Amyloid 1–42 (Aβ1–42)-Induced Hippocampal Inflammatory Response, p-tau, Vascular Pathology, and Their Synergistic Contributions to …

B Calvo-Flores Guzmán, T Elizabeth Chaffey… - Frontiers in Molecular …, 2020 - frontiersin.org
Alzheimer's disease (AD), the most common chronic neurodegenerative disorder, has
complex neuropathology. The principal neuropathological hallmarks of the disease are the …

Current status of drug targets and emerging therapeutic strategies in the management of Alzheimer's disease

S Ghosh, S Durgvanshi, S Agarwal… - Current …, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease affecting the elderly. AD is
associated with a progressive decline in memory and cognitive abilities, drastic changes in …