The goal of this review is to present a comprehensive survey of the many intriguing facets of
creatine (Cr) and creatinine metabolism, encompassing the pathways and regulation of Cr …

Background Biomarkers of peripheral muscle fatigue (BPMFs) are used to offer insights into
mechanisms of exhaustion during exercise in order to detect abnormal fatigue or to detect …

Creatine kinase (CK) is a key enzyme for maintaining a constant ATP/ADP ratio during rapid
energy turnover. To investigate the role of CK in skeletal muscle fatigue, we used isolated …

Evidence for the important physiological role of the creatine kinase (CK)–phosphocreatine
(PCr) system in energy homeostasis in sarcomeric muscle, brain, and other organs of high …

The diaphragm muscle (DIAm) is a highly active muscle of mixed fiber type composition. We
hypothesized that consistent with greater activation history and proportion of fatigue …

The ability to perform well in activities that require muscular and cardiorespiratory
endurance is a trait influenced, in a considerable part, by the genetic makeup of individuals …

To assess the significance of energy supply routes in cellular energetic homeostasis, net
phosphoryl fluxes catalyzed by creatine kinase (CK), adenylate kinase (AK) and glycolytic …

Previously we demonstrated that efficient coupling between cellular sites of ATP production
and ATP utilization, required for optimal muscle performance, is mainly mediated by the …

Creatine kinase (CK) is an abundant enzyme, important for maintenance of high-energy
phosphate homeostasis in many tissues including heart. Double-knockout CK (DbKO-CK) …

The distribution of allele and genotype frequencies of the muscle-specific creatine kinase
(CKMM) gene A/G polymorphism in athletes (n= 384) and control subjects (n= 1116) was …