The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

Abstract Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a
developmental and epileptic encephalopathy with infantile-onset epilepsy. Most individuals …

CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disease caused
by mutations in the X-linked CDKL 5 gene, is characterized by early-onset epilepsy …

Genetic sequencing technologies have led to an increase in the identification and
characterization of monogenic epilepsy syndromes. This increase has, in turn, generated …

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a rare
neurodevelopmental disease caused by mutations in the X-linked CDKL5 gene. CDD is …

Many neurodevelopmental disorders (NDDs) are the result of mutations on the X
chromosome. One severe NDD resulting from mutations on the X chromosome is CDKL5 …

A rare disease is defined by its low prevalence in the general population. Although the fixed
threshold slightly varies between different countries, a specific disorder is usually …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and is a major
health threat globally. Its prevalence is forecasted to exponentially increase during the next …

Epilepsy is one of the most common brain disorders that not only causes death worldwide,
but also affects the daily lives of patients. Previous studies have revealed that inflammation …

Despite recent FDA approvals, Alzheimer's disease (AD) still represents an unmet medical
need. Among the different available therapeutic approaches, the development of multitarget …