[HTML][HTML] The molecular pathology of schizophrenia: An overview of existing knowledge and new directions for future research
T Nakamura, A Takata - Molecular Psychiatry, 2023 - nature.com
Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …
[HTML][HTML] Lessons learned from parsing genetic risk for schizophrenia into biological pathways
The clinically heterogeneous presentation of schizophrenia is compounded by the
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …
heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide …
GIP receptor agonism attenuates GLP-1 receptor agonist–induced nausea and emesis in preclinical models
Glucagon-like peptide 1 receptor (GLP-1R) agonists decrease body weight and improve
glycemic control in obesity and diabetes. Patient compliance and maximal efficacy of GLP-1 …
glycemic control in obesity and diabetes. Patient compliance and maximal efficacy of GLP-1 …
[HTML][HTML] Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes
Major depressive disorder (MDD) is a common, heterogenous, and potentially serious
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
psychiatric illness. Diverse brain cell types have been implicated in MDD etiology …
[HTML][HTML] Single nucleus transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine …
Opioid exposure is known to cause transcriptomic changes in the nucleus accumbens
(NAc). However, no studies to date have investigated cell type-specific transcriptomic …
(NAc). However, no studies to date have investigated cell type-specific transcriptomic …
[HTML][HTML] Antipsychotic drug use complicates assessment of gene expression changes associated with schizophrenia
A Schulmann, S Marenco, MP Vawter, N Akula… - Translational …, 2023 - nature.com
Recent postmortem transcriptomic studies of schizophrenia (SCZ) have shown hundreds of
differentially expressed genes. However, the extent to which these gene expression …
differentially expressed genes. However, the extent to which these gene expression …
Single-cell multi-cohort dissection of the schizophrenia transcriptome
The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation
and the development of more effective therapies. Here, we performed single-cell dissection …
and the development of more effective therapies. Here, we performed single-cell dissection …
Relating enhancer genetic variation across mammals to complex phenotypes using machine learning
Protein-coding differences between species often fail to explain phenotypic diversity,
suggesting the involvement of genomic elements that regulate gene expression such as …
suggesting the involvement of genomic elements that regulate gene expression such as …
Extraction of nuclei from archived postmortem tissues for single-nucleus sequencing applications
Single-cell and single-nucleus sequencing techniques are a burgeoning field with various
biological, biomedical and clinical applications. Numerous high-and low-throughput …
biological, biomedical and clinical applications. Numerous high-and low-throughput …
[HTML][HTML] Single nuclei RNA sequencing of the rat AP and NTS following GDF15 treatment
Objective Growth differentiation factor 15 (GDF15) is known to play a role in feeding,
nausea, and body weight, with action through the GFRAL-RET receptor complex in the area …
nausea, and body weight, with action through the GFRAL-RET receptor complex in the area …