Supramolecular organic frameworks: exploring water-soluble, regular nanopores for biomedical applications

ZT Li, SB Yu, Y Liu, J Tian… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus In past decades, regular porous architectures have received a great amount of
attention because of their versatile functions and applications derived from their efficient …

Anticoagulation reversal (vitamin K, prothrombin complex concentrates, idarucizumab, andexanet‐α, protamine)

E Bekka, E Liakoni - British journal of clinical pharmacology, 2024 - Wiley Online Library
Bleeding events are common in patients prescribed anticoagulants and can have
devastating consequences. Several specific and nonspecific agents have been developed …

Porous polymers as universal reversal agents for heparin anticoagulants through an inclusion–sequestration mechanism

F Lin, SB Yu, YY Liu, CZ Liu, S Lu, J Cao… - Advanced …, 2022 - Wiley Online Library
Heparins are widely used anticoagulants for surgical procedures and extracorporeal
therapies. However, all of them have bleeding risks. Protamine sulfate, the only clinically …

Heparin reversal by an oligoethylene glycol functionalized guanidinocalixarene

Q Huang, H Zhao, M Shui, DS Guo, R Wang - Chemical Science, 2020 - pubs.rsc.org
Unfractionated heparin (UFH), a naturally occurring anionic polysaccharide, is widely used
as an anticoagulant agent in clinical practice. When overdosed or used in sensitive patients …

A tetracationic aggregation induced emission-based probe for efficient and improved detection of Heparin

SP Pandey, P Jha, DN Nadimetla, SV Bhosale… - Sensors and Actuators B …, 2022 - Elsevier
Designing efficient fluorescent probes with Aggregation Induced Emission (AIE) feature,
especially for sensing biologically important analytes, is an intensive area of investigation …

Caltrop-like Small-Molecule Antidotes That Neutralize Unfractionated Heparin and Low-Molecular-Weight Heparin In Vivo

Y Zong, Z Lei, SB Yu, LY Zhang, Y Wu… - Journal of Medicinal …, 2024 - ACS Publications
Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs) are widely
applied for surgical procedures and extracorporeal therapies, which, however, suffer …

External Trigger Free Charge Switchable Cationic Ligands in the Design of Safe and Effective Universal Heparin Antidote

CC La, SA Smith, MT Kalathottukaren… - Advanced …, 2024 - Wiley Online Library
Thrombosis, the formation of blood clots within a blood vessel, can lead to severe
complications including pulmonary embolism, cardiac arrest, and stroke. The most widely …

Anticoagulant macromolecules

X Wang, MK Hadi, J Niu, Q Zhou, F Ran - Macromolecules, 2023 - ACS Publications
Anticoagulant macromolecules have gained widespread use in the clinical treatment of
cardiovascular diseases, blood-contacting or implantable materials, and medical devices …

Construction of a highly sensitive detection platform for heparin based on a “turn-off” cationic fluorescent dye

Y Liu, Y Zhang, C Liu, C Wang, B Xu, L Zhao - Spectrochimica Acta Part A …, 2024 - Elsevier
A highly sensitive detection platform for heparin was constructed via the utilization of a
commercially available cationic fluorescent dye (cresyl violet acetate, CV) as a fluorescence …

High affinity heparin detection by multivalent supramolecular polymers through aggregation induced emission

SK Bhaumik, YS Patra, S Banerjee - Chemical Communications, 2020 - pubs.rsc.org
Amphiphilic di-cationic cyanostilbene derivatives with aggregation induced emission (AIE)
features formed luminescent supramolecular polymers in aqueous media. They bind bio …