Preeclampsia is defined as new-onset hypertension after the 20th wk of gestation along with
evidence of maternal organ failure. Rates of preeclampsia have steadily increased over the …

Developmental programming of non-communicable diseases is now an established
paradigm. With respect to hypertension and chronic kidney disease, adverse events …

Dr David Barker first popularized the concept of fetal origins of adult disease (FOAD). Since
its inception, FOAD has received considerable attention. The FOAD hypothesis holds that …

Low birth weight serves as a crude proxy for impaired growth during fetal life and indicates a
failure for the fetus to achieve its full growth potential. Low birth weight can occur in …

Background: Fetal Growth Restriction (FGR) is one of the most common noxious antenatal
conditions in humans, inducing a substantial proportion of preterm delivery and leading to a …

Size at birth is a critical determinant of life expectancy, and is dependent primarily on the
placental supply of nutrients. However, the placenta is not just a passive organ for the …

Abundant evidence supports the association between low birth weight (LBW) and renal
dysfunction in humans. Anatomic measurements of infants, children, and adults show …

One of the leading global public-health burdens is metabolic syndrome (MetS), despite the
many advances in pharmacotherapies. MetS, now known as “developmental origins of …

Babies born small are at an increased risk of developing myriad adult diseases. While
growth restriction increases disease risk in all individuals, often a second hit is required to …

Pre-eclampsia is increasingly recognized as more than an isolated disease of pregnancy.
Women who have had a pregnancy complicated by pre-eclampsia have a 4-fold increased …