Lipid-based nanoparticles for delivery of vaccine adjuvants and antigens: toward multicomponent vaccines
D Chatzikleanthous, DT O'Hagan… - Molecular …, 2021 - ACS Publications
Despite the many advances that have occurred in the field of vaccine adjuvants, there are
still unmet needs that may enable the development of vaccines suitable for more …
still unmet needs that may enable the development of vaccines suitable for more …
[HTML][HTML] Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants
Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …
The multirole of liposomes in therapy and prevention of infectious diseases
R Nisini, N Poerio, S Mariotti, F De Santis… - Frontiers in …, 2018 - frontiersin.org
Liposomes are closed bilayer structures spontaneously formed by hydrated phospholipids
that are widely used as efficient delivery systems for drugs or antigens, due to their capability …
that are widely used as efficient delivery systems for drugs or antigens, due to their capability …
The role of toll-like receptor agonists and their nanomedicines for tumor immunotherapy
L Huang, X Ge, Y Liu, H Li, Z Zhang - Pharmaceutics, 2022 - mdpi.com
Toll-like receptors (TLRs) are a class of pattern recognition receptors that play a critical role
in innate and adaptive immunity. Toll-like receptor agonists (TLRa) as vaccine adjuvant …
in innate and adaptive immunity. Toll-like receptor agonists (TLRa) as vaccine adjuvant …
Development of thermosensitive resiquimod-loaded liposomes for enhanced cancer immunotherapy
Resiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and
immunostimulatory activity. However, systemic delivery of R848 is poorly tolerated because …
immunostimulatory activity. However, systemic delivery of R848 is poorly tolerated because …
Synthetic polymeric mixed micelles targeting lymph nodes trigger enhanced cellular and humoral immune responses
It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines
because antigen presentation and initiation of T-cell-mediated immune responses occur …
because antigen presentation and initiation of T-cell-mediated immune responses occur …
Advances in engineered polymer nanoparticle tracking platforms towards cancer immunotherapy—Current status and future perspectives
Engineering polymeric nanoparticles for their shape, size, surface chemistry, and
functionalization using various targeting molecules has shown improved biomedical …
functionalization using various targeting molecules has shown improved biomedical …
Immunotherapeutic implications of toll-like receptors activation in tumor microenvironment
R Zheng, J Ma - Pharmaceutics, 2022 - mdpi.com
Toll-like receptors (TLRs) play an important role between innate and adaptive immunity as
one of the pattern recognition receptors (PRRs). Both immune cells and tumor cells express …
one of the pattern recognition receptors (PRRs). Both immune cells and tumor cells express …
Toll-like receptor-targeted particles: a paradigm to manipulate the tumor microenvironment for cancer immunotherapy
The expression of Toll-like receptors (TLRs) on antigen presenting cells, especially dendritic
cells, offers several sensitive mediators to trigger an adaptive immune response, which …
cells, offers several sensitive mediators to trigger an adaptive immune response, which …
Employing drug delivery strategies to overcome challenges using TLR7/8 agonists for cancer immunotherapy
Toll-like receptors (TLRs) are a potential target for cancer immunotherapy due to their role in
the activation of the innate immune system. More specifically, TLR7 and TLR8, two …
the activation of the innate immune system. More specifically, TLR7 and TLR8, two …