Erdheim-Chester disease (ECD) is a rare histiocytosis that was recently recognized as a
neoplastic disorder owing to the discovery of recurrent activating MAPK (RAS-RAF-MEK …

Erdheim-Chester disease (ECD) is a rare, multisystemic, inflammatory, non–Langerhans cell
histiocytic neoplasm. The discovery of recurrent and somatic mutations in the mitogen …

Langerhans cell histiocytosis (LCH) can affect children and adults with a wide variety of
clinical manifestations, including unifocal, single-system multifocal, single-system pulmonary …

Histiocytic neoplasms are rare hematologic disorders accounting for less than 1% of cancers
of the soft tissue and lymph nodes. Clinical presentation and prognosis of these disorders …

Rosai-Dorfman disease (RDD) is a rare histiocytosis with heterogenous clinical features. In
this study, we characterized the histologic and phenotypic features in 33 RDD patients to …

Histiocytoses are heterogeneous hematopoietic diseases characterized by the accumulation
of CD68 (+) cells with various admixed inflammatory infiltrates. The identification of the …

Histiocytic disorders are an exceptionally rare group of diseases with diverse manifestations
and a paucity of approved treatments, thereby leading to various challenges in their …

Histiocytosis is a rare inflammatory process characterized by pathologic infiltration and
accumulation of cells derived from the monocytic lineage in normal tissue. It encompasses …

Langerhans cell histiocytosis (LCH) is a histiocytic neoplasm that can involve the lungs as
single system (LCH‐SSL) or multisystem disease (LCH‐MSL). The role of full‐body …

Erdheim–Chester disease (ECD) is a rare clonal histiocytic neoplasm with less than 1200
documented cases to date. The disease is life-threatening and difficult to recognize …