ESX secretion systems: mycobacterial evolution to counter host immunity
MI Gröschel, F Sayes, R Simeone, L Majlessi… - Nature Reviews …, 2016 - nature.com
Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …
Vaccines against tuberculosis: where are we and where do we need to go?
THM Ottenhoff, SHE Kaufmann - PLoS pathogens, 2012 - journals.plos.org
In this review we discuss recent progress in the development, testing, and clinical evaluation
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …
CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent …
S Sakai, KD Kauffman, MA Sallin, AH Sharpe… - PLoS …, 2016 - journals.plos.org
IFN-γ–producing CD4 T cells are required for protection against Mycobacterium tuberculosis
(Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated …
(Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated …
Scaling up interventions to achieve global tuberculosis control: progress and new developments
M Raviglione, B Marais, K Floyd, K Lönnroth… - The Lancet, 2012 - thelancet.com
Tuberculosis is still one of the most important causes of death worldwide. The 2010 Lancet
tuberculosis series provided a comprehensive overview of global control efforts and …
tuberculosis series provided a comprehensive overview of global control efforts and …
Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence
JAM Tufariello, JR Chapman… - Proceedings of the …, 2016 - National Acad Sciences
Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS),
designated ESX-1–ESX-5, that are critical for growth and pathogenesis. The best …
designated ESX-1–ESX-5, that are critical for growth and pathogenesis. The best …
[HTML][HTML] Features of the biochemistry of Mycobacterium smegmatis, as a possible model for Mycobacterium tuberculosis
J Ranjitha, A Rajan, V Shankar - Journal of infection and public health, 2020 - Elsevier
An alternate host for mycobacteria is Mycobacterium smegmatis which is used frequently. It
is a directly budding eco-friendly organism not emulated as human infection. It is mainly …
is a directly budding eco-friendly organism not emulated as human infection. It is mainly …
GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections
Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain;
however, the roles of GABA in antimicrobial host defenses are largely unknown. Here we …
however, the roles of GABA in antimicrobial host defenses are largely unknown. Here we …
Memory T Cells in Latent Mycobacterium tuberculosis Infection Are Directed against Three Antigenic Islands and Largely Contained in a CXCR3+CCR6+ Th1 …
An understanding of the immunological footprint of Mycobacterium tuberculosis (MTB) CD4
T cell recognition is still incomplete. Here we report that human Th1 cells specific for MTB …
T cell recognition is still incomplete. Here we report that human Th1 cells specific for MTB …
Bovine tuberculosis vaccine research: historical perspectives and recent advances
WR Waters, MV Palmer, BM Buddle, HM Vordermeier - Vaccine, 2012 - Elsevier
The emergence of wildlife reservoirs of Mycobacterium bovis infection in cattle as well as
increased inter-regional trade with associated spread of M. bovis has led to renewed interest …
increased inter-regional trade with associated spread of M. bovis has led to renewed interest …
PPAR-α activation mediates innate host defense through induction of TFEB and lipid catabolism
The role of peroxisome proliferator–activated receptor α (PPAR-α) in innate host defense is
largely unknown. In this study, we show that PPAR-α is essential for antimycobacterial …
largely unknown. In this study, we show that PPAR-α is essential for antimycobacterial …