Multi-scale modeling of the cardiovascular system: disease development, progression, and clinical intervention

Y Zhang, VH Barocas, SA Berceli, CE Clancy… - Annals of biomedical …, 2016 - Springer
Cardiovascular diseases (CVDs) are the leading cause of death in the western world. With
the current development of clinical diagnostics to more accurately measure the extent and …

Mathematical modelling and simulation of atherosclerosis formation and progress: a review

NA Avgerinos, P Neofytou - Annals of Biomedical Engineering, 2019 - Springer
Cardiovascular disease (CVD) is a major threat to human health since it is the leading cause
of death in western countries. Atherosclerosis is a type of CVD related to hypertension …

Mathematical modeling of inflammatory processes of atherosclerosis

G Abi Younes, N El Khatib - Mathematical Modelling of Natural …, 2022 - mmnp-journal.org
Atherosclerosis is a chronic disease which involves the build up of cholesterol and fatty
deposits within the inner lining of the artery. It is associated with a progressive thickening …

Computational modelling of atherosclerosis

A Parton, V McGilligan, M O'Kane… - Briefings in …, 2016 - academic.oup.com
Atherosclerosis is one of the principle pathologies of cardiovascular disease with blood
cholesterol a significant risk factor. The World Health Organization estimates that …

Bifurcation and dynamics in a mathematical model of early atherosclerosis: How acute inflammation drives lesion development

AD Chalmers, A Cohen, CA Bursill… - Journal of mathematical …, 2015 - Springer
We present here a mathematical model describing the primary mechanisms that drive the
early stages of atherosclerosis. This involves the interactions between modified low density …

Identifying important parameters in the inflammatory process with a mathematical model of immune cell influx and macrophage polarization

M Torres, J Wang, PJ Yannie, S Ghosh… - PLoS computational …, 2019 - journals.plos.org
In an inflammatory setting, macrophages can be polarized to an inflammatory M1 phenotype
or to an anti-inflammatory M2 phenotype, as well as existing on a spectrum between these …

Long time evolution of atherosclerotic plaques

MAK Bulelzai, JLA Dubbeldam - Journal of theoretical biology, 2012 - Elsevier
The evolution of atherosclerosis in general, and the influence of wall shear stress on the
growth of atherosclerotic plaques in particular, is an intricate phenomenon which is still only …

A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure

MP Little, A Gola, I Tzoulaki - PLoS computational biology, 2009 - journals.plos.org
Atherosclerosis is the main cause of coronary heart disease and stroke, the two major
causes of death in developed society. There is emerging evidence of excess risk of …

Mathematical modeling and simulation of the evolution of plaques in blood vessels

Y Yang, W Jäger, M Neuss-Radu, T Richter - Journal of mathematical …, 2016 - Springer
In this paper, a model is developed for the evolution of plaques in arteries, which is one of
the main causes for the blockage of blood flow. Plaque rupture and spread of torn-off …

An ODE model of early stages of atherosclerosis: mechanisms of the inflammatory response

A Ougrinovskaia, RS Thompson… - Bulletin of mathematical …, 2010 - Springer
Atherosclerosis is a chronic disease of the large arteries, characterized by fatty cholesterol-
filled streaks and plaque build-up within the artery wall. Within the past decade …