Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation

PCA van der Wel - Biochemical Society Transactions, 2024 - portlandpress.com
The aggregation of proteins into amyloid-like fibrils is seen in many neurodegenerative
diseases. Recent years have seen much progress in our understanding of these misfolded …

1D Ultrathin Peptoid Nanobelts‐Based Organic‐Inorganic Nanocomposite for Photo‐Controllable Chemo‐Enzymatic Cascade Catalysis

P Wu, P Sui, Z Xu, L Zhu, Y Jia, S Dai… - Advanced Functional …, 2024 - Wiley Online Library
The development of 1D stimuli‐responsive ultrathin organic nanomaterials (UTONMs)‐
based hybrid nanocomposites with tailored functions is necessitated to construct hybrid …

Chiral structures in azobenzene‐containing systems: Construction, regulation, and application

Z He, X Cheng, Z Wang, W Zhang - Responsive Materials, 2024 - Wiley Online Library
Chirality is a fundamental property in nature, which is essential for the existence and survival
of living organisms. Smart responsive chiroptical materials have garnered increasing …

Azobenzene-Tagged Photopeptides Exhibiting Excellent Selectivity and Light-Induced Cytotoxicity in MCF-7 Cells over HeLa and A549

S Pradhan, S Sarker, P Thilagar - Journal of Medicinal Chemistry, 2024 - ACS Publications
The precise regulation of proteasome activity has become a focal point in current research,
particularly its implications in cancer treatment. Bortezomib is used for treating multiple …

Photocontrolled Reversible Amyloid Fibril Formation of Parathyroid Hormone-Derived Peptides

A Paschold, M Schäffler, X Miao, L Gardon… - Bioconjugate …, 2024 - ACS Publications
Peptide fibrillization is crucial in biological processes such as amyloid-related diseases and
hormone storage, involving complex transitions between folded, unfolded, and aggregated …

Spiropyran as Building Block in Peptide Synthesis and Modulation of Photochromic Properties

A Paschold, N Starke, S Rothemund, WH Binder - Organic Letters, 2024 - ACS Publications
Light-controlled triggering of materials requires efficient embedding of molecular
photoswitches into larger molecules. We herein present the synthesis of two new building …

Inhibitor-based modulation of huntingtin aggregation reduces fibril toxicity

G Jain, M Trombetta-Lima, I Matlahov, HT Ribas… - bioRxiv, 2023 - biorxiv.org
Huntington's disease (HD) is a neurodegenerative disorder caused by the expansion of the
polyglutamine (polyQ) segment in the exon 1 of the huntingtin (HttEx1) protein. This polyQ …