Emerging themes in CryoEM─ Single particle analysis image processing
Cryo-electron microscopy (CryoEM) has become a vital technique in structural biology. It is
an interdisciplinary field that takes advantage of advances in biochemistry, physics, and …
an interdisciplinary field that takes advantage of advances in biochemistry, physics, and …
The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation
T Ginex, C Marco-Marín, M Wieczór, CP Mata… - PLoS …, 2022 - journals.plos.org
The S: A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-
CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared …
CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared …
Recovery of conformational continuum from single-particle Cryo-EM images: Optimization of ManifoldEM informed by ground truth
This work is based on the manifold-embedding approach to study biological molecules
exhibiting continuous conformational changes. Previous work established a method—now …
exhibiting continuous conformational changes. Previous work established a method—now …
[HTML][HTML] A Bayesian framework for cryo-EM heterogeneity analysis using regularized covariance estimation
Proteins and the complexes they form are central to nearly all cellular processes. Their
flexibility, expressed through a continuum of states, provides a window into their biological …
flexibility, expressed through a continuum of states, provides a window into their biological …
Molecular Insights into Macromolecules Structure, Function, and Regulation
Z Yang, J Zhao - International Journal of Molecular Sciences, 2024 - mdpi.com
Macromolecules exhibit ordered structures and complex functions in an aqueous
environment with strong thermodynamic fluctuations. The all-atom spatial–temporal …
environment with strong thermodynamic fluctuations. The all-atom spatial–temporal …
Energy landscapes from cryo-EM snapshots: a benchmarking study
R Dsouza, G Mashayekhi, R Etemadpour… - Scientific reports, 2023 - nature.com
Biomolecules undergo continuous conformational motions, a subset of which are
functionally relevant. Understanding, and ultimately controlling biomolecular function are …
functionally relevant. Understanding, and ultimately controlling biomolecular function are …
[图书][B] Analysis of conformational continuum and free-energy landscapes from manifold embedding of single-particle Cryo-EM ensembles of biomolecules
E Seitz - 2022 - search.proquest.com
Biological molecules, or molecular machines, visit a continuum of conformational states as
they go through work cycles required for their metabolic functions. Single-molecule cryo-EM …
they go through work cycles required for their metabolic functions. Single-molecule cryo-EM …