Visualization of the cellular heterogeneity and spatial architecture of the tumor
microenvironment (TME) is becoming increasingly important to understand mechanisms of …

Tissues and organs are composed of distinct cell types that must operate in concert to
perform physiological functions. Efforts to create high-dimensional biomarker catalogs of …

CD8+ T cells are essential components of the immune response against viral infections and
tumours, and are capable of eliminating infected and cancerous cells. However, when the …

Most studies of adaptive immunity to SARS-CoV-2 infection focus on peripheral blood, which
may not fully reflect immune responses at the site of infection. Using samples from 110 …

Multiplexed antibody-based imaging enables the detailed characterization of molecular and
cellular organization in tissues. Advances in the field now allow high-parameter data …

Tissues are complex environments where different cell types are in constant interaction with
each other and with non-cellular components. Preserving the spatial context during …

Although virus–host interactions are usually studied in a single cell type using in vitro assays
in immortalized cell lines or isolated cell populations, it is important to remember that what is …

Traditional immunohistochemistry (IHC) has already become an essential method of
diagnosis and therapy in cancer management. However, this antibody-based technique is …

Lupus nephritis is a serious complication of systemic lupus erythematosus, mediated by IgG
immune complex (IC) deposition in kidneys, with limited treatment options. Kidney …

Advances in immunology, immuno-oncology, drug discovery and vaccine development
demand improvements in the capabilities of flow cytometry to allow it to measure more …