The integration of nucleic acid amplification (NAA) with the CRISPR detection system has
led to significant advancements and opportunities for development in molecular diagnostics …

DNA amplification technologies have significantly advanced biotechnology, particularly in
DNA storage. However, adaptation of these technologies to DNA storage poses substantial …

Deciphering the context-specific relationship between sequence and function is a major
challenge in genomics. Existing tools for inducing locus-specific hypermutation and …

Antimicrobial resistance (AMR) represents a substantial threat to global public health,
complicating the treatment of common infections and leading to prolonged illness and …

The detection of genetic material (DNA or RNA) is becoming increasingly important not only
in the clinical practice but also in food quality control or environmental analysis. Since the …

Foodborne pathogens such as Salmonella, Escherichia coli and Listeria pose significant
risks to human health. The World Health Organization estimates that 2.2 million deaths per …

Free energies (FEs) in molecular sciences can be used to quantify the stability of folded
molecules. In this article, we introduce nanopores for measuring FEs. We pull DNA hairpin …

Engineering a protein variant with a desired role relies on deep knowledge of the
relationship between a protein's native structure and function. Using our structural …

Helicases, which utilize ATP hydrolysis to separate nucleic acid duplexes, play crucial roles
in DNA and RNA replication, repair, recombination, and transcription. Categorized into the …

Abstract Interferon-γ-inducible protein 10 (IP-10) has demonstrated enormous potential as a
novel biomarker for tuberculosis (TB), particularly in the monitoring of patient progression for …