Nucleic acids are not only expected to assume a pivotal position as “drugs” in the treatment
of genetic and acquired diseases, but could also act as molecular cues to control the …

Since the demonstration of RNA interference (RNAi) in mammalian cells, considerable
research and financial effort has gone towards implementing RNAi as a viable therapeutic …

Polycations that absorb protons in response to the acidification of endosomes can
theoretically disrupt these vesicles via the “proton sponge” effect. To exploit this mechanism …

Cationic liposomes (CLs) composed of 3β-[N-(N′, N′-dimethylaminoethane) carbamoyl]
cholesterol (DC-Chol) and dioleoylphosphatidylethanolamine (DOPE)(DC-Chol/DOPE …

Polyethylene imine (PEI) based polycations, successfully used for gene therapy or RNA
interference in vitro as well as in vivo, have been shown to cause well-known adverse side …

Gene therapy based on small interfering RNA (siRNA) has emerged as an exciting new
therapeutic approach. However, insufficient cellular uptake and poor stability have limited its …

Colloidal drug delivery systems present a range of therapeutic benefits in the treatment of a
number of challenging conditions, allowing researchers to cross barriers that have …

Background Small interfering (si) RNA mediated inhibition of oncogenes or viral genes may
offer great opportunities for the treatment of several diseases such as hepatocellular …

Most cationic liposomes used for gene delivery suffer from reduced transfection efficiency in
the presence of serum. In this study, we report serum-enhanced delivery efficiency of siRNA …

5-Fluorouracil (5-FU) is broadly considered the drug of choice for treating human colorectal
cancer (CRC). However, 5-FU resistance, mainly caused by the overexpression of …