Endothelial metabolic control of insulin sensitivity through resident macrophages

J Zhang, KA Sjøberg, S Gong, T Wang, F Li, A Kuo… - Cell Metabolism, 2024 - cell.com
Endothelial cells (ECs) not only form passive blood conduits but actively contribute to
nutrient transport and organ homeostasis. The role of ECs in glucose homeostasis is …

Exploring the therapeutic potential of fibroadipogenic progenitors in muscle disease

MW Hogarth, MP Kurukunda, K Ismat… - Journal of …, 2025 - journals.sagepub.com
Skeletal muscle relies on its inherent self-repair ability to withstand continuous mechanical
damage. Myofiber-intrinsic processes facilitate the repair of damage to sarcolemma and …

A comprehensive single-cell RNA transcriptomic analysis identifies a unique SPP1+ macrophages subgroup in aging skeletal muscle

W Bi, M Yang, M Shi, M Hou, C Jiang, G Fan, W Guo - Scientific Reports, 2024 - nature.com
Senescence of skeletal muscle (SkM) has been a primary contributor to senior weakness
and disability in recent years. The gradually declining SkM function associated with …

Dermatopontin-expressing fibroblasts mediate an essential skin macrophage niche

AC Vollmers, SZ Wu, A Altieri, EE McCartney, H Bender… - bioRxiv, 2024 - biorxiv.org
Fibroblasts are present in all tissues and are crucial for maintaining tissue homeostasis. We
previously identified fibroblasts marked by Dermatopontin (Dpt) but their role in supporting …

Complementing Muscle Regeneration: Fibro-Adipogenic Progenitor and Macrophage-Mediated Repair of Elderly Human Skeletal Muscle

J Farup, J Brorson, L Lin, J Wang, T Billeskov, J Just… - 2024 - researchsquare.com
The capacity to regenerate skeletal muscle function after injury requires a complex and well-
coordinated cellular response, which is challenged in aged skeletal muscle. Here, we …