Since the advent of penicillin, the β-lactam antibiotics have been the subject of much
discussion and investigation within both the scientific and public sectors. β-Lactam …

More than a decade ago, the question was raised by Sweeney if aziridines are epoxides'
ugly cousins? 1 The overview on the biological properties, synthetic accessibility, and useful …

Cycloaddition reactions between ketenes, bearing amino‐, oxy‐, or halo‐groups, and imines
are recognized as being amongst the most important and direct routes to β‐lactams. Alkyl …

The report by Staudinger in 1907 of the reactions of diphenylketene (1) with
benzylideneaniline (2), benzaldehyde, and cyclopentadiene forming [2þ2] adducts 3–5 …

Since the advent of penicillin, the β-lactam antibiotics have been the subject of much
discussion and investigation, within both the scientific and public sectors. The primary …

In the last two decades, the better understanding of the mechanistic aspects of the β-lactams'
biological activity and their inhibition, and the chemical exploitation of β-lactams as synthetic …

The chemistry of tetramethyldisiloxane (TMDS) is largely composed of the reduction of
functional groups with increasing applications for carbon–carbon bond formation. This …

4-Oxoazetidine-2-carbaldehydes or 4-formyl-β-lactams can be considered both as protected
α-amino aldehydes and masked β-amino acids. These bifunctional compounds exhibit a …

Besides their biological activity, the importance of β-lactams as synthetic intermediates has
been widely recognized in organic synthesis because ring cleavage of any of the four single …

The synthesis of enantiomerically pure modified proline derivatives was achieved by using
spiro β-lactams as starting material that were prepared in turn by the [2+ 2]-cycloaddition of …