Evolution and diversity of assembly-line polyketide synthases: Focus review

A Nivina, KP Yuet, J Hsu, C Khosla - Chemical reviews, 2019 - ACS Publications
Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

The genetic and ecophysiological diversity of Microcystis

GJ Dick, MB Duhaime, JT Evans… - Environmental …, 2021 - Wiley Online Library
Microcystis is a cyanobacterium that forms toxic blooms in freshwater ecosystems around
the world. Biological variation among taxa within the genus is apparent through genetic and …

The Black Queen Hypothesis: evolution of dependencies through adaptive gene loss

JJ Morris, RE Lenski, ER Zinser - MBio, 2012 - Am Soc Microbiol
Reductive genomic evolution, driven by genetic drift, is common in endosymbiotic bacteria.
Genome reduction is less common in free-living organisms, but it has occurred in the …

Bioactive natural products from marine cyanobacteria for drug discovery

LT Tan - Phytochemistry, 2007 - Elsevier
The prokaryotic marine cyanobacteria continue to be an important source of structurally
bioactive secondary metabolites. A majority of these molecules are nitrogen-containing …

Cyanobacteria: an emerging source for drug discovery

RK Singh, SP Tiwari, AK Rai, TM Mohapatra - The Journal of antibiotics, 2011 - nature.com
The c group of Gram-negative gliding bacteria, has a long history of cosmopolitan
occurrence. It has great biodiversity despite the absence of sexual reproduction. This wide …

Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics

S Donadio, P Monciardini, M Sosio - Natural product reports, 2007 - pubs.rsc.org
Covering: bacterial genome sequences to 2005 and post-genomic literature to June 2006 A
total of 223 complete bacterial genomes are analyzed, with 281 citations, for the presence of …

Iron uptake mechanisms in marine phytoplankton

R Sutak, JM Camadro, E Lesuisse - Frontiers in microbiology, 2020 - frontiersin.org
Oceanic phytoplankton species have highly efficient mechanisms of iron acquisition, as they
can take up iron from environments in which it is present at subnanomolar concentrations. In …

Azaspiracid shellfish poisoning: a review on the chemistry, ecology, and toxicology with an emphasis on human health impacts

MJ Twiner, N Rehmann, P Hess, GJ Doucette - Marine drugs, 2008 - mdpi.com
Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species
and have been associated with severe gastrointestinal human intoxications since 1995. This …

Highly plastic genome of Microcystis aeruginosa PCC 7806, a ubiquitous toxic freshwater cyanobacterium

L Frangeul, P Quillardet, AM Castets, JF Humbert… - BMC genomics, 2008 - Springer
Abstract Background The colonial cyanobacterium Microcystis proliferates in a wide range of
freshwater ecosystems and is exposed to changing environmental factors during its life …

Chemodiversity in freshwater and terrestrial cyanobacteria-a source for drug discovery

GE Chlipala, S Mo, J Orjala - Current drug targets, 2011 - ingentaconnect.com
Cyanobacteria are considered a promising source for new pharmaceutical lead compounds
and a large number of chemically diverse and bioactive metabolites have been obtained …