Significance of preexisting vector immunity and activation of innate responses for adenoviral vector-based therapy
An adenoviral (AdV)-based vector system is a promising platform for vaccine development
and gene therapy applications. Administration of an AdV vector elicits robust innate …
and gene therapy applications. Administration of an AdV vector elicits robust innate …
Development of novel adenoviral vectors to overcome challenges observed with HAdV-5–based constructs
Recombinant vectors based on human adenovirus serotype 5 (HAdV-5) have been
extensively studied in preclinical models and clinical trials over the past two decades …
extensively studied in preclinical models and clinical trials over the past two decades …
A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice
Although the BCG vaccine offers partial protection, tuberculosis remains a leading cause of
infectious disease death, killing∼ 1.5 million people annually. We developed mucosal …
infectious disease death, killing∼ 1.5 million people annually. We developed mucosal …
Circumventing antivector immunity: potential use of nonhuman adenoviral vectors
E Lopez-Gordo, II Podgorski, N Downes… - Human gene …, 2014 - liebertpub.com
Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide
variety of cell types and drive high-level transient transgene expression. While there have …
variety of cell types and drive high-level transient transgene expression. While there have …
Enhancement of mucosal innate and adaptive immunity following intranasal immunization of mice with a bovine adenoviral vector
EE Sayedahmed, NO Elshafie, GJ Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction Nonhuman adenoviral (AdV) gene delivery platforms have significant value due
to their ability to elude preexisting AdV vector immunity in most individuals. Previously, we …
to their ability to elude preexisting AdV vector immunity in most individuals. Previously, we …
Nonhuman adenoviral vector-based platforms and their utility in designing next generation of vaccines for infectious diseases
Several human adenoviral (Ad) vectors have been developed for vaccine delivery owing to
their numerous advantages, including the feasibility of different vector designs, the …
their numerous advantages, including the feasibility of different vector designs, the …
EphrinA1–EphA2 interaction‐mediated apoptosis and FMS‐like tyrosine kinase 3 receptor ligand‐induced immunotherapy inhibit tumor growth in a breast cancer …
Background The receptor tyrosine kinase EphA2 is overexpressed in several types of
cancers and is currently being pursued as a target for breast cancer therapeutics. The …
cancers and is currently being pursued as a target for breast cancer therapeutics. The …
Subcutaneous immunization with recombinant adenovirus expressing influenza A nucleoprotein protects mice against lethal viral challenge
A Hashem, B Jaentschke, C Gravel… - Human Vaccines & …, 2012 - Taylor & Francis
Current influenza vaccines mainly induce strain-specific neutralizing antibodies and need to
be updated each year, resulting in significant burdens on vaccine manufacturers and …
be updated each year, resulting in significant burdens on vaccine manufacturers and …
In vitro and in vivo tropism and biodistribution of recombinant simian adenovirus type 25
IV Vavilova, TA Ozharovskaia, OV Zubkova… - Journal of …, 2024 - microbiol.crie.ru
Introduction. Recombinant adenoviruses are widely used in the development of vaccines for
a variety of infectious diseases. Despite numerous clinical studies, only a few types of …
a variety of infectious diseases. Despite numerous clinical studies, only a few types of …
Xenogenic adenoviral vectors
Many nonhuman adenoviruses (AdVs) of simian, bovine, porcine, canine, ovine, murine,
and fowl origin are being developed as gene delivery systems for recombinant vaccines and …
and fowl origin are being developed as gene delivery systems for recombinant vaccines and …