Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic
properties that can differentially promote progression, metastasis and drug resistance …

BACKGROUND Chromatin is the essential medium through which transcription factors,
signaling pathways, and other cues alter gene activity and cellular phenotypes. It assumes …

Glioblastoma, the most common and aggressive malignant brain tumor, is propagated by
stem-like cancer cells refractory to existing therapies. Understanding the molecular …

The outcomes for the majority of patients with myeloma have improved over recent decades,
driven by treatment advances. However, there is a subset of patients considered to have …

Summary Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …

The genetic evolutionary features of solid tumour growth are becoming increasingly well
described, but the spatial and physical nature of subclonal growth remains unclear. Here …

Tumour hypoxia is a major contributor to resistance to anticancer therapies. Given that the
results of hypoxia-targeted therapy trials have been disappointing, a more personalized …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

Alterations in the epigenome and metabolism affect molecular rewiring of cancer cells
facilitating cancer development and progression. Modulation of histone and DNA …