Highlights•PAS domains are common sensing, signaling, dimerization, and localization
domains.•Sensing versatility derives from a conserved cleft that binds cofactors and …

Bacteria depend on two-component systems to detect and respond to threats. Simple
pathways comprise a single sensor kinase (SK) that detects a signal and activates a …

Selective recruitment and concentration of signalling proteins within membraneless
compartments is a ubiquitous mechanism for subcellular organization,–. The dynamic flow of …

Bacterial signaling histidine kinases (HKs) have long been postulated to function exclusively
through linear signal transduction chains. However, several HKs have recently been shown …

Scaffolding proteins can customize the response of signaling networks to support cell
development and behaviors. PleC is a bifunctional histidine kinase whose signaling activity …

Asymmetric cell division in bacteria is achieved through cell polarization, where regulatory
proteins are directed to specific cell poles. In Caulobacter crescentus, both poles contain a …

An integrative approach to visualization is used to create a visual snapshot of the structural
biology of the polar microdomain of Caulobacter crescentus. The visualization is based on …

The cyanobacterial clock presents a unique opportunity to understand the biochemical basis
of circadian rhythms. The core oscillator, composed of the KaiA, KaiB, and KaiC proteins …

Histidine kinases (HK) switch between conformational states that promote kinase and
phosphatase activities to regulate diverse cellular processes. Past studies have shown that …

While many bacteria divide by symmetric binary fission, some alphaproteobacteria have
strikingly asymmetric cell cycles, producing offspring that differs significantly in their …