Simple Summary Inflammation is assessed as a hallmark of cancer and it is now widely
recognized that there exists a direct causal link between inflammation and tumors. Among …

Cyclooxygenases-2 (COX-2) and Prostaglandin E2 (PGE2), which are important in chronic
inflammatory diseases, can increase tumor incidence and promote tumor growth and …

A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

Aspirin (acetylsalicylic acid) has become one of the most commonly used drugs, given its
role as an analgesic, antipyretic and agent for cardiovascular prophylaxis. Several decades …

Chronic inflammation is a known risk factor for gastrointestinal cancer. The evidence that
nonsteroidal anti-inflammatory drugs suppress the incidence, growth, and metastasis of …

Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology.
From the earliest observation that Wnt overexpression could lead to malignant …

Abstract Prostaglandin E 2 (PGE 2) is a bioactive lipid that elicits a wide range of biological
effects associated with inflammation and cancer. PGE 2 exerts diverse effects on cell …

This review gives an account of recent advances in our knowledge of the molecular
mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic …

Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that
have been implicated in various pathological processes, such as inflammation and cancer …

The place of aspirin in primary prevention remains controversial, with North American and
European organizations issuing contradictory treatment guidelines. More recently, the US …