As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …

Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

INTRODUCTION Mitochondria provide cells with energy and numerous essential
metabolites such as lipids, amino acids, iron sulfur clusters, and heme. All mitochondrial …

Mitochondrial biogenesis and functions depend on the import of precursor proteins via the
'translocase of the outer membrane'(TOM complex). Defects in protein import lead to an …

INTRODUCTION Eukaryotic cells contain membrane-bound organelles with distinct
identities and functionalities that depend on protein composition. Correct localization of …

The nascent polypeptide–associated complex (NAC) interacts with newly synthesized
proteins at the ribosomal tunnel exit and competes with the signal recognition particle (SRP) …

BACKGROUND Evolution generally trundles along by selecting for mutations or by
leveraging the new realms generated from chromosomal amplifications and the transfer of …