This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

A pronounced heterogeneity between hepatocytes in subcellular structure and enzyme
activities was discovered more than 50 years ago and initiated the idea of metabolic …

Polyamines are small organic polycations that are absolutely required for cell growth and
proliferation; yet the basis for this requirement is mostly unknown. Here, we combined a …

Background & Aims The differentiation of stem cells to hepatocyte-like cells (HLC) offers the
perspective of unlimited supply of human hepatocytes. However, the degree of …

Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In
addition, currently available in vitro methods do not allow for the estimation of hepatotoxic …

The association between an adverse early life environment and increased susceptibility to
later-life metabolic disorders such as obesity, type 2 diabetes and cardiovascular disease is …

The application of primary human hepatocytes following isolation from human tissue is well
accepted to be compromised by the process of dedifferentiation. This phenomenon reduces …

A long-term goal of numerous research projects is to identify biomarkers for in vitro systems
predicting toxicity in vivo. Often, transcriptomics data are used to identify candidates for …

Queuosine is one of the most complex hypermodified RNA nucleosides found in the Wobble
position of tRNAs. In addition to Queuosine itself, several further modified derivatives are …

The adult liver has an exceptional ability to regenerate, but how it maintains its specialized
functions during regeneration is unclear. Here, we used partial hepatectomy (PHx) in …