The tumour suppressor gene TP53 is mutated in~ 50% of human cancers. In addition to its
function in tumour suppression, p53 also plays a major role in the response of malignant as …

Progress in strategies aimed at breaking down therapeutic target proteins has led to a
paradigm shift in drug discovery. Thalidomide and its derivatives are the only protein …

The p53 tumor suppressor acts to integrate multiple stress signals into a series of diverse
antiproliferative responses. One of the most important p53 functions is its ability to activate …

Mutations that drive uncontrolled cell-cycle progression are requisite events in
tumorigenesis. But evolution has installed in the proliferative programmes of mammalian …

Mutations are rare events, occurring spontaneously at a frequency of 1 per 109-1010 base
pairs per cell division. 1, 2 Nucleotide misincorporation during DNA synthesis yields …

The p53 tumor-suppressor plays a critical role in the prevention of human cancer. In the
absence of cellular stress, the p53 protein is maintained at low steady-state levels and …

The distinguishing feature of adult stem cells is their extraordinary capacity to divide prior to
the onset of senescence. While stratified epithelia such as skin, prostate, and breast are …

The recently discovered p53-related genes, p73 and p63, express multiple splice variants
and N-terminally truncated forms initiated from an alternative promoter in intron 3. To date …

The p53 pathway is composed of hundreds of genes and their products that respond to a
wide variety of stress signals. These responses to stress include apoptosis, cellular …

Even 30 years after its discovery, the tumor suppressor protein p53 is still somewhat of an
enigma. p53's intimate and multifaceted role in the cell cycle is mirrored in its equally …