Hydroxynitrile Lyase Discovery, Engineering, and Promiscuity towards Asymmetric Synthesis: Recent Progress

BV Priya, SK Padhi - European Journal of Organic Chemistry, 2023 - Wiley Online Library
Hydroxynitrile lyases (HNLs) primarily catalyze the stereoselective synthesis of
cyanohydrins, but some of them also carry out asymmetric nitroaldol synthesis (Henry …

Nitrile biosynthesis in nature: how and why?

M Liu, S Li - Natural Product Reports, 2024 - pubs.rsc.org
Covering: up to the end of 2023 Natural nitriles comprise a small set of secondary
metabolites which however show intriguing chemical and functional diversity. Various …

R‐hydroxynitrile lyase from the cyanogenic millipede, Chamberlinius hualienensis—A new entry to the carrier protein family Lipocalines

F Motojima, A Izumi, A Nuylert, Z Zhai… - The FEBS …, 2021 - Wiley Online Library
Hydroxynitrile lyases (HNLs) catalyze the cleavage of cyanohydrin into cyanide and the
corresponding aldehyde or ketone. Moreover, they catalyze the synthesis of cyanohydrin in …

Nandina domestica Thunb.: a review of traditional uses, phytochemistry, pharmacology, and toxicology

H Qian, Y Li - Frontiers in Pharmacology, 2024 - frontiersin.org
Nandina domestica: Thunb. is a traditional Chinese herbal drug that has long been used in
China and Japan for the treatment of colds, fevers, asthma, chronic bronchitis, conjunctivitis …

A High‐Throughput Screening Method for the Directed Evolution of Hydroxynitrile Lyase towards Cyanohydrin Synthesis

YC Zheng, LY Ding, Q Jia, Z Lin, R Hong… - …, 2021 - Wiley Online Library
Chiral cyanohydrins are useful intermediates in the pharmaceutical and agricultural
industries. In nature, hydroxynitrile lyases (HNLs) are a kind of elegant tool for …

Stabilization of Hydroxynitrile Lyases from Two Variants of Passion Fruit, Passiflora edulis Sims and Passiflora edulis Forma flavicarpa, by C‐Terminal Truncation

A Nuylert, F Motojima, C Khanongnuch… - …, 2020 - Wiley Online Library
Because the synthesis of chiral compounds generally requires a broad range of substrate
specificity and stable enzymes, screening for better enzymes and/or improvement of enzyme …

[PDF][PDF] MALAYSIAN JOURNAL OF BIOCHEMISTRY & MOLECULAR BIOLOGY

AI Lutfi, N Kritsanayanyong, SND Rahim, NB Saidi… - researchgate.net
Accepted: 1 August 2022 Pathogenesis-related 10 (PR-10) is a defense-related protein that
provides adaptive responses to various biotic and abiotic stimuli. It was characterized by …

[PDF][PDF] Natural Product Reports

C Li, SS Ragab, G Liu, W Tang - environments - researchgate.net
Pentacyclic triterpenoids are important natural bioactive substances that are widely present
in plants and fungi. They have significant medicinal efficacy, play an important role in …

[HTML][HTML] ヤスデ由来のヒドロキシニトリルリアーゼの発見と構造に関する研究

浅野泰久 - Journal of Japanese Biochemical Society, 2022 - seikagaku.jbsoc.or.jp
Journal of Japanese Biochemical Society 94(5): 681-689 (2022) ロゴ 生化学 SEIKAGAKU
Journal of Japanese Biochemical Society Online ISSN: 2189-0544 Print ISSN: 0037-1017 公益 …

[PDF][PDF] ニュイラ―トエムNuylert Aem

シアン生成能を有する植物およびヤスデにおけるヒドロキシ … - 2020 - pu-toyama.repo.nii.ac.jp
Hydroxynitrile lyases (HNLs, EC 4.1. 2.10, 4.1. 2.11, 4.1. 2.46, and 4.1. 2.47) act during the
final step of the cyanohydrin biodegradation pathway. 1, 2) In cyanogenic plants, HNL plays …