Maternal‐driven immune education in offspring

KA Fernandes, AI Lim - Immunological Reviews, 2024 - Wiley Online Library
Maternal environmental exposures, particularly during gestation and lactation, significantly
influence the immunological development and long‐term immunity of offspring. Mammalian …

Systemic Immune Modulation by Gastrointestinal Nematodes

DN Kasal, L Warner, A Bryant… - Annual Review of …, 2024 - annualreviews.org
Gastrointestinal nematode (GIN) infection has applied significant evolutionary pressure to
the mammalian immune system and remains a global economic and human health burden …

BCG mediated protection of the lung against experimental SARS-CoV-2 infection

KL Hilligan, S Namasivayam, A Sher - Frontiers in Immunology, 2023 - frontiersin.org
The observation of reduced COVID-19 incidence and severity in populations receiving
neonatal intradermal BCG vaccination vaccine raised the question of whether BCG can …

Helminth alleviates COVID-19-related cytokine storm in an IL-9-dependent way

Z Cao, J Wang, X Liu, Y Liu, F Li, M Liu, S Chiu, X Jin - Mbio, 2024 - Am Soc Microbiol
Hyperactivation of pro-inflammatory type 1 cytokines (eg, tumor necrosis factor alpha [TNF-α]
and interferon gamma [IFN-γ]) mirrors the inflammation of coronavirus disease 2019 …

Th2-biased immune responses to body migrating Ascaris larvae in primary infection are associated with pathology but not protection

LE Elizalde-Velázquez, J Schlosser-Brandenburg… - Scientific Reports, 2024 - nature.com
Helminth infections lead to an overdispersion of the parasites in humans as well as in
animals. We asked whether early immune responses against migrating Ascaris larvae are …

Helminth infection induces a distinct subset of CD101hi lung tissue–infiltrating eosinophils that are differentially regulated by type 2 cytokines

SL Noble, F Vacca, KL Hilligan… - … and Cell Biology, 2024 - Wiley Online Library
Eosinophils play divergent roles in health and disease, contributing to both
immunoregulatory and proinflammatory responses. Helminth infection is strongly associated …

Clinical outcome and peripheral immune profile of myasthenic crisis with omicron infections: A prospective cohort study

X Huan, J Chen, H Zhong, Y Xu, Y Wang, H Jiang… - Clinical …, 2024 - Elsevier
The impact of Omicron infections on the clinical outcome and immune responses of
myasthenia gravis (MG) remained largely unknown. From a prospective multicenter MG …

IL-9 plays a critical role in helminth-induced protection against COVID-19-related cytokine storms

CX Xiang, G Zhong, H Wang - mBio, 2024 - Am Soc Microbiol
ABSTRACT A recent study published in mBio by Cao et al. demonstrated that the helminth
Trichinella sprialis (Ts) alleviates COVID-19-related cytokine storms in an IL-9-dependent …

Lung-migrating helminths can enhance immunity to SARS-CoV-2

Y Bordon - Nature Reviews Immunology, 2023 - nature.com
There have been conflicting views on whether helminth infections modulate disease
outcomes during SARS-CoV-2 infection. In this study, Oyesola et al. infected K18-hACE2 …

Targeting helminths: The expanding world of type 2 immune effector mechanisms

RM Maizels, WC Gause - Journal of Experimental Medicine, 2023 - rupress.org
Type 2 immune responses underpin critical physiological processes, from protection against
metazoan endo-and ectoparasites, through metabolic adaptation and homeostasis, to tissue …