Depression in sleep disturbance: a review on a bidirectional relationship, mechanisms and treatment
Sleep disturbance is the most prominent symptom in depressive patients and was formerly
regarded as a main secondary manifestation of depression. However, many longitudinal …
regarded as a main secondary manifestation of depression. However, many longitudinal …
Major depressive disorder: advances in neuroscience research and translational applications
Z Li, M Ruan, J Chen, Y Fang - Neuroscience bulletin, 2021 - Springer
Major depressive disorder (MDD), also referred to as depression, is one of the most common
psychiatric disorders with a high economic burden. The etiology of depression is still not …
psychiatric disorders with a high economic burden. The etiology of depression is still not …
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study
Importance Most previous genome-wide association studies (GWAS) of depression have
used data from individuals of European descent. This limits the understanding of the …
used data from individuals of European descent. This limits the understanding of the …
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Depression is a common, devastating illness. Current pharmacotherapies help many
patients, but high rates of a partial response or no response, and the delayed onset of the …
patients, but high rates of a partial response or no response, and the delayed onset of the …
Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model-are we there yet?
E Jesulola, P Micalos, IJ Baguley - Behavioural brain research, 2018 - Elsevier
A number of factors (biogenic amine deficiency, genetic, environmental, immunologic,
endocrine factors and neurogenesis) have been identified as mechanisms which provide …
endocrine factors and neurogenesis) have been identified as mechanisms which provide …
The genetics of stress-related disorders: PTSD, depression, and anxiety disorders
JW Smoller - Neuropsychopharmacology, 2016 - nature.com
Research into the causes of psychopathology has largely focused on two broad etiologic
factors: genetic vulnerability and environmental stressors. An important role for …
factors: genetic vulnerability and environmental stressors. An important role for …
Biomarkers for depression: recent insights, current challenges and future prospects
A plethora of research has implicated hundreds of putative biomarkers for depression, but
has not yet fully elucidated their roles in depressive illness or established what is abnormal …
has not yet fully elucidated their roles in depressive illness or established what is abnormal …
Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression
RC Culverhouse, NL Saccone, AC Horton, Y Ma… - Molecular …, 2018 - nature.com
The hypothesis that the S allele of the 5-HTTLPR serotonin transporter promoter region is
associated with increased risk of depression, but only in individuals exposed to stressful …
associated with increased risk of depression, but only in individuals exposed to stressful …
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Depression is more frequent among individuals exposed to traumatic events. Both trauma
exposure and depression are heritable. However, the relationship between these traits …
exposure and depression are heritable. However, the relationship between these traits …