Mitochondrial dysfunction and mitochondrial therapies in heart failure

C Wu, Z Zhang, W Zhang, X Liu - Pharmacological Research, 2022 - Elsevier
Cardiovascular diseases remain the leading cause of death worldwide in the last decade,
accompanied by immense health and economic burdens. Heart failure (HF), as the terminal …

The effect of resveratrol on the cardiovascular system from molecular mechanisms to clinical results

R Gal, L Deres, K Toth, R Halmosi, T Habon - International journal of …, 2021 - mdpi.com
Cardiovascular diseases are the leading causes of death worldwide. The cardioprotective
effects of natural polyphenols such as resveratrol (3, 5, 4-trihydroxystilbene) have been …

The role of resveratrol in mild cognitive impairment and Alzheimer's disease: a systematic review

DS Buglio, LT Marton, LF Laurindo… - Journal of Medicinal …, 2022 - liebertpub.com
Advancing age is one of the risk factors for developing many diseases, including cancer,
cardiovascular disorders, and neurodegenerative alterations, such as mild cognitive …

Resveratrol for the management of human health: how far have we come? A systematic review of resveratrol clinical trials to highlight gaps and opportunities

K Brown, D Theofanous, RG Britton, G Aburido… - International Journal of …, 2024 - mdpi.com
Resveratrol has long been proposed as being beneficial to human health across multiple
morbidities, yet there is currently no conclusive clinical evidence to advocate its …

A comprehensive analysis of the efficacy of resveratrol in atherosclerotic cardiovascular disease, myocardial infarction and heart failure

P Raj, SJ Thandapilly, J Wigle, S Zieroth, T Netticadan - Molecules, 2021 - mdpi.com
Atherosclerosis, myocardial infarction (MI) and heart failure (HF) are the main causes of
mortality and morbidity around the globe. New therapies are needed to better manage …

Targeting calcium regulators as therapy for heart failure: Focus on the sarcoplasmic reticulum Ca-ATPase pump

C Kho - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Impaired myocardial Ca2+ cycling is a critical contributor to the development of heart failure
(HF), causing changes in the contractile function and structure remodeling of the heart …

Effects of resveratrol supplementation on cardiac remodeling in hypertensive patients: a randomized controlled clinical trial

X Zheng, J Hai, Y Yang, C Zhang, X Ma, B Kong… - Hypertension …, 2023 - nature.com
Resveratrol (RES) has been demonstrated to be protective in the cardiovascular system in
animal studies, but the evidence is limited in humans. The purpose of the study was to …

Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences

L Pang, X Jiang, X Lian, J Chen, EF Song, LG Jin… - Military Medical …, 2022 - Springer
The literature is full of claims regarding the consumption of polyphenol or polyamine-rich
foods that offer some protection from developing cardiovascular disease (CVD). This is …

Resveratrol and beyond: The effect of natural polyphenols on the cardiovascular system: A narrative review

R Gál, R Halmosi, F Gallyas Jr, M Tschida… - Biomedicines, 2023 - mdpi.com
Cardiovascular diseases (CVDs) are among the leading causes of morbidity and mortality
worldwide. Unhealthy dietary habits have clearly been shown to contribute to the …

Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration

M Jhanji, CN Rao, JC Massey, MC Hope III… - Nature …, 2022 - nature.com
Serum tyrosine levels increase during aging, neurocognitive, metabolic, and cardiovascular
disorders. However, calorie restriction (CR) and sleep lower serum tyrosine levels. We …