Organisms must survive a variety of stressful conditions, including sudden temperature
increases that damage important cellular structures and interfere with essential functions. In …

The past decade of efforts to find improved treatment for major depression has been
dominated by genome-driven programs of rational drug discovery directed toward highly …

" Our thoughts are meaningful. We think about things in the outside world; how can that be
so? This is one of the deepest questions in contemporary philosophy. Ever since …

Background Grapevine metabolism in response to water deficit was studied in two cultivars,
Shiraz and Cabernet Sauvignon, which were shown to have different hydraulic behaviors …

Background This paper proposes a novel model for homeopathic remedy action on living
systems. Research indicates that homeopathic remedies (a) contain measurable source and …

Despite improved rational drug design and a remarkable progress in genomic, proteomic
and high-throughput screening methods, the number of novel, single-target drugs has fallen …

Molecular chaperones are central to cellular protein homeostasis. In mammals, protein
misfolding diseases and aging cause inflammation and progressive tissue loss, in …

Aging at the molecular level is characterized by the progressive accumulation of molecular
damage. The sources of damage act randomly through environmental and metabolically …

Active centres and hot spots of proteins have a paramount importance in enzyme action,
protein-complex formation and drug design. Recently, several publications successfully …

Researchers are increasingly focused on the nanoscale level of organization where
biological processes take place in living systems. Nanoparticles (NPs, eg, 1–100 nm …