Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Sepsis is characterized by complex pathophysiology and heterogeneous phenotypes of
affected patients regarding their symptoms, response to treatment, and outcomes. At present …

Lipopolysaccharide (LPS) provokes severe inflammation and cell death in sepsis, with liver
being the major affected organ. Up-to-date, neither the mechanism of action nor target …

Clinical and technological advances promoting early hemorrhage control and physiologic
resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly …

Abstract miR-21 is aberrantly expressed, and plays a role in various types of tumors and
many other diseases. However, the mechanism of miR-21 in LPS-induced septic shock is …

Background Sepsis is a leading cause of death in intensive care units (ICUs), but outcomes
of individual patients are difficult to predict. The recently developed clinical metabolomics …

Sepsis is recognized as a life‐threatening organ dysfunctional disease that is caused by
dysregulated host responses to infection. Up to now, sepsis still remains a dominant cause …

Nontyphoidal salmonellae (NTS) are a major cause of invasive (iNTS) disease in sub-
Saharan Africa, manifesting as bacteremia and meningitis. Available epidemiological data …

In many respects, genetic studies in cystic fibrosis (CF) serve as a paradigm for a human
Mendelian genetic success story. From recognition of the condition as a heritable …

Infections are common and need minimal treatment; however, occasionally, due to
inappropriate immune response, they can develop into a life-threatening condition known as …