Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer-related death. Most cases of CRC are detected in Western countries, with its …

Abstract Hydrogen peroxide (H 2 O 2) is involved in various signal transduction pathways
and cell fate decisions. The mechanism of the so called “redox signaling” includes the H 2 O …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Disulfide bridges establish a fundamental element in the molecular architecture of proteins
and peptides which are involved eg, in basic biological processes or acting as toxins. NMR …

Background Within cells, there is a narrow concentration threshold that governs whether
reactive oxygen species (ROS) induce toxicity or act as second messengers. Scope of …

Natural or synthetic chalcones with different substituents have revealed a variety of
biological activities that may benefit human health. The underlying mechanisms of action …

Thioredoxin reductases (TrxRs) belong to the pyridine nucleotide disulfide oxidoreductase
family enzymes that reduce thioredoxin (Trx). The couple TrxR and Trx is one of the major …

Significance: All cells must maintain a balance between oxidants and reductants, while
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …