Nucleic acid aptamers are promising alternatives to antibodies in analytics. They are
generally obtained through an iterative SELEX protocol that enriches a population of …

Affinity reagents are essential tools in both basic and applied research; however, there is a
growing concern about the reproducibility of animal-derived monoclonal antibodies. The …

Aptamers are single-stranded oligonucleotides that fold into well-defined three-dimensional
shapes, allowing them to bind their targets with high affinity and specificity. They can be …

Many biological processes (physiological or pathological) are relevant to membrane
proteins (MPs), which account for almost 30% of the total of human proteins. As such, MPs …

In addition to the helical nature of double-stranded DNA and RNA, single-stranded
oligonucleotides can arrange themselves into tridimensional structures containing loops …

The cocaine aptamer has been seen as a good candidate for development as a probe for
cocaine in many contexts. Here, we demonstrate that the aptamer binds cocaine …

We develop a multivalent aptamer meshed open pore membrane with a signal amplification
method as a simple and robust platform for sensitive, robust, and high-flux detection of E …

We describe a ribonucleic acid (RNA) reporter system for live-cell imaging of gene
expression to detect changes in polymerase II activity on individual promoters in individual …

Isothermal titration calorimetry (ITC) is a powerful label-free technique to determine the
binding constant as well as thermodynamic parameters of a binding reaction and is …

Aptamers can be highly specific for their targets, which implies precise molecular recognition
between aptamer and target. However, as small polymers, their structures are more subject …