The role of MSC in wound healing, scarring and regeneration

R Guillamat-Prats - Cells, 2021 - mdpi.com
Tissue repair and regeneration after damage is not completely understood, and current
therapies to support this process are limited. The wound healing process is associated with …

The pros and cons of mesenchymal stem cell-based therapies

A Musiał-Wysocka, M Kot, M Majka - Cell transplantation, 2019 - journals.sagepub.com
The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …

Improved MSC minimal criteria to maximize patient safety: a call to embrace tissue factor and hemocompatibility assessment of MSC products

G Moll, JA Ankrum, SD Olson… - Stem cells translational …, 2022 - academic.oup.com
The number of mesenchymal stromal/stem cell (MSC) therapeutics and types of clinical
applications have greatly diversified during the past decade, including rapid growth of poorly …

Intravascular mesenchymal stromal/stem cell therapy product diversification: time for new clinical guidelines

G Moll, JA Ankrum, J Kamhieh-Milz, K Bieback… - Trends in molecular …, 2019 - cell.com
Intravascular infusion is the most popular route for therapeutic multipotent mesenchymal
stromal/stem cell (MSC) delivery in hundreds of clinical trials. Meta-analysis has …

Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving β-cell destruction

Y Sun, H Shi, S Yin, C Ji, X Zhang, B Zhang, P Wu… - ACS …, 2018 - ACS Publications
Exosomes are nanosized extracellular vesicles (EVs) that show great promise in tissue
regeneration and injury repair as mesenchymal stem cell (MSC). MSC has been shown to …

MSC-derived extracellular vesicles attenuate immune responses in two autoimmune murine models: type 1 diabetes and uveoretinitis

T Shigemoto-Kuroda, JY Oh, D Kim, HJ Jeong, SY Park… - Stem cell reports, 2017 - cell.com
Accumulating evidence shows that extracellular vesicles (EVs) produced by mesenchymal
stem/stromal cells (MSCs) exert their therapeutic effects in several disease models. We …

[HTML][HTML] Advances in regenerative therapy: A review of the literature and future directions

EH Ntege, H Sunami, Y Shimizu - Regenerative therapy, 2020 - Elsevier
There is enormous global anticipation for stem cell-based therapies that are safe and
effective. Numerous pre-clinical studies present encouraging results on the therapeutic …

Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties?

G Moll, JJ Alm, LC Davies, L von Bahr, N Heldring… - Stem …, 2014 - academic.oup.com
We have recently reported that therapeutic mesenchymal stromal cells (MSCs) have low
engraftment and trigger the instant blood mediated inflammatory reaction (IBMIR) after …

Therapeutic potential of multipotent mesenchymal stromal cells and their extracellular vesicles

N Heldring, I Mäger, MJA Wood, K Le Blanc… - Human gene …, 2015 - liebertpub.com
The therapeutic potential of mesenchymal stromal cells (MSCs) is evident by the number of
new and ongoing trials targeting an impressive variety of conditions. In bone and cartilage …

Effect of MSCs and MSC-derived extracellular vesicles on human blood coagulation

DN Silachev, KV Goryunov, MA Shpilyuk… - Cells, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) have emerged as a potent therapeutic tool for the treatment
of a number of pathologies, including immune pathologies. However, unwelcome effects of …