Resident microglial cells can be regarded as the immunological watchdogs of the brain and
the retina. They are active sensors of their neuronal microenvironment and rapidly respond …

Corneal transplantation is the most successful solid organ transplantation performed in
humans. The extraordinary success of orthotopic corneal allografts, in both humans and …

In recent years, many paradigms concerning central nervous system (CNS) immunology
have been challenged and shifted, including the discovery of CNS-draining lymphatic …

Abstract Changes in microglial cell activation and distribution are associated with neuronal
decline in the central nervous system (CNS), particularly under pathological conditions …

The glaucomas are neurodegenerative diseases involving death of retinal ganglion cells
and optic nerve head excavation. A major risk factor for this neurodegeneration is a …

purpose. Structures derived from periocular mesenchyme arise by complex interactions
between neural crest and mesoderm. Defects in development or function of structures …

purpose. In the context of the retinal ganglion cell (RGC) axon degeneration in the optic
nerve that occurs in glaucoma, microglia become activated, then phagocytic, and …

Background Glaucoma is a chronic neurodegenerative disease of the retina, characterized
by the degeneration of axons in the optic nerve and retinal ganglion cell apoptosis. DBA/2J …

The process of inflammation requires the selective expression of a suite of genes in cells of
the macrophage lineage. To identify candidate regulators of inflammation, we used cDNA …

Neuroprotection can be defined as any therapeutic paradigm designed to prevent or delay
neuronal cell death and maintain neural function. In glaucoma, progressive death of the …