Regulation of inflammation by the antioxidant haem oxygenase 1

NK Campbell, HK Fitzgerald, A Dunne - Nature Reviews Immunology, 2021 - nature.com
Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …

Gasotransmitters in cancer: from pathophysiology to experimental therapy

C Szabo - Nature reviews Drug discovery, 2016 - nature.com
The three endogenous gaseous transmitters—nitric oxide (NO), carbon monoxide (CO) and
hydrogen sulfide (H2S)—regulate a number of key biological functions. Emerging data have …

Gas-mediated cancer bioimaging and therapy

L Chen, SF Zhou, L Su, J Song - ACS nano, 2019 - ACS Publications
Gas-involving cancer theranostics have attracted considerable attention in recent years due
to their high therapeutic efficacy and biosafety. We have reviewed the recent significant …

Carbon monoxide and its controlled release: therapeutic application, detection, and development of carbon monoxide releasing molecules (CORMs) miniperspective

K Ling, F Men, WC Wang, YQ Zhou… - Journal of Medicinal …, 2017 - ACS Publications
Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

Acute exacerbation of COPD

FW Ko, KP Chan, DS Hui, JR Goddard, JG Shaw… - …, 2016 - Wiley Online Library
The literature of acute exacerbation of chronic obstructive pulmonary disease (COPD) is fast
expanding. This review focuses on several aspects of acute exacerbation of COPD …

Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation

SW Ryter, AMK Choi - Translational Research, 2016 - Elsevier
The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Heme oxygenases in cardiovascular health and disease

A Ayer, A Zarjou, A Agarwal… - Physiological …, 2016 - journals.physiology.org
Heme oxygenases are composed of two isozymes, Hmox1 and Hmox2, that catalyze the
degradation of heme to carbon monoxide (CO), ferrous iron, and biliverdin, the latter of …

Does air pollution modify temperature-related mortality? A systematic review and meta-analysis

X Hu, W Han, Y Wang, K Aunan, X Pan, J Huang… - Environmental …, 2022 - Elsevier
Introduction There is an increasing interest in understanding whether air pollutants modify
the quantitative relationships between temperature and health outcomes. The results of …

Heme oxygenase-1/carbon monoxide as modulators of autophagy and inflammation

SW Ryter - Archives of biochemistry and biophysics, 2019 - Elsevier
Abstract Heme oxygenase-1 (HO-1) catalyzes heme degradation to generate biliverdin-IXα,
carbon monoxide (CO), and iron. The HO-1/CO system confers cytoprotection in animal …

Emerging delivery strategies of carbon monoxide for therapeutic applications: from CO gas to CO releasing nanomaterials

H Yan, J Du, S Zhu, G Nie, H Zhang, Z Gu, Y Zhao - Small, 2019 - Wiley Online Library
Carbon monoxide (CO) therapy has emerged as a hot topic under exploration in the field of
gas therapy as it shows the promise of treating various diseases. Due to the gaseous …