Liver disease causing end organ failure is a growing cause of mortality. In most cases, the
only therapy is liver transplantation. However, liver transplantation is a complex undertaking …

Although liver transplantation is a true success story, many patients still die awaiting an
organ. The increasing need for liver grafts therefore remains an unsolved challenge to the …

The number of donor organs suitable for liver transplantation is restricted by cold
preservation and ischemia–reperfusion injury. We present the first patients transplanted …

Objective: The aim of this study was to evaluate sequential hypothermic and normothermic
machine perfusion (NMP) as a tool to resuscitate and assess viability of initially declined …

Ex situ normothermic machine perfusion (NMP) is increasingly used for viability assessment
of high‐risk donor livers, whereas dual hypothermic oxygenated machine perfusion …

Background Experimental studies have suggested that end-ischaemic dual hypothermic
oxygenated machine perfusion (DHOPE) may restore hepatocellular energy status and …

Organs recovered from donors after circulatory death (DCD) suffer warm ischemia before
cold storage which may prejudice graft survival and result in a greater risk of complications …

In 1958 Francis Moore described the orthotopic liver transplantation technique in dogs. In
1963, Starzl et al. performed the first liver transplantation. In the first five liver …

The inability to preserve vascular organs beyond several hours contributes to the scarcity of
organs for transplantation,. Standard hypothermic preservation at+ 4° C (refs.,) limits liver …

Background & Aims Due to ethical rules in most countries, long ischemia times are
unavoidable prior to organ procurement of donors without a heartbeat, which can cause …