[HTML][HTML] Biofilm lifestyle in recurrent urinary tract infections

ASA Lila, AAH Rajab, MH Abdallah, SMD Rizvi, A Moin… - Life, 2023 - mdpi.com
Urinary tract infections (UTIs) represent one of the most common infections that are
frequently encountered in health care facilities. One of the main mechanisms used by …

[HTML][HTML] Critical Assessment of the Prospects of Quorum-Quenching Therapy for Staphylococcus aureus Infection

M Otto - International Journal of Molecular Sciences, 2023 - mdpi.com
Staphylococcus aureus is an important pathogen that causes a high number of infections
and is one of the leading causes of death in hospitalized patients. Widespread antibiotic …

[HTML][HTML] Characterization of the anti-biofilm and anti-quorum sensing activities of the β-adrenoreceptor antagonist atenolol against gram-negative bacterial pathogens

S Cavalu, SS Elbaramawi, AG Eissa… - International Journal of …, 2022 - mdpi.com
The development of bacterial resistance to antibiotics is an increasing public health issue
that worsens with the formation of biofilms. Quorum sensing (QS) orchestrates the bacterial …

Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria

MA Elfaky, SS Elbaramawi, AG Eissa… - Applied Microbiology …, 2023 - Springer
The resistance development is an increasing global health risk that needs innovative
solutions. Repurposing drugs to serve as anti-virulence agents is suggested as an …

[HTML][HTML] Molecular modeling study of micro and nanocurcumin with in vitro and in vivo antibacterial validation

AS Othman, IM Shamekh, M Abdalla, WA Eltayb… - Scientific Reports, 2023 - nature.com
Repurposing natural compounds as inhibitory targets to combat bacterial virulence is an
important potential strategy to overcome resistance to traditional antibiotics, in the present …

[HTML][HTML] Antibiofilm and Anti-Quorum-Sensing Activities of Novel Pyrazole and Pyrazolo[1,5-a]pyrimidine Derivatives as Carbonic Anhydrase I and II Inhibitors: Design …

A Ragab, SA Fouad, YA Ammar, DS Aboul-Magd… - Antibiotics, 2023 - mdpi.com
Nowadays, searching for new anti-infective agents with diverse mechanisms of action has
become necessary. In this study, 16 pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives …

[HTML][HTML] What's old is new again: Insights into diabetic foot microbiome

AAH Rajab, WAH Hegazy - World Journal of Diabetes, 2023 - ncbi.nlm.nih.gov
Diabetes is a chronic disease that is considered one of the most stubborn global health
problems that continues to defy the efforts of scientists and physicians. The prevalence of …

[HTML][HTML] Diminishing the Pathogenesis of the Food-Borne Pathogen Serratia marcescens by Low Doses of Sodium Citrate

MT Khayat, SS Elbaramawi, SI Nazeih, MK Safo… - Biology, 2023 - mdpi.com
Simple Summary Sodium citrate is a safe and frequently used food additive; the objective of
this study is to assess the effectiveness of sodium citrate at low concentrations of 4% or 5 …

[HTML][HTML] Silencing of Salmonella typhimurium Pathogenesis: Atenolol Acquires Efficient Anti-Virulence Activities

AK Thabit, K Eljaaly, A Zawawi, TS Ibrahim, AG Eissa… - Microorganisms, 2022 - mdpi.com
The targeting of bacterial virulence is proposed as a promising approach to overcoming the
bacterial resistance development to antibiotics. Salmonella enterica is one of the most …

[HTML][HTML] Relocating Glyceryl Trinitrate as an Anti-Virulence Agent against Pseudomonas aeruginosa and Serratia marcescens: Insights from Molecular and In Vivo …

SI Nazeih, MAM Ali, ASA Halim, H Al-Lawati, HA Abbas… - Microorganisms, 2023 - mdpi.com
The problem of antibiotic resistance is a global critical public health concern. In light of the
threat of returning to the pre-antibiotic era, new alternative approaches are required such as …