Surface curvature both emerges from, and influences the behavior of, living objects at length
scales ranging from cell membranes to single cells to tissues and organs. The relevance of …

The way in which interactions between mechanics and biochemistry lead to the emergence
of complex cell and tissue organization is an old question that has recently attracted …

During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers—
endoderm, mesoderm and ectoderm, which eventually form the entire embryo. Decades of …

Human primordial germ cells (hPGCs) form around the time of implantation and are the
precursors of eggs and sperm. Many aspects of hPGC specification remain poorly …

Primordial germ cell (PGC) specification is the first step in the development of the germline.
Recent work has elucidated human-mouse differences in PGC differentiation and identified …

In recent years, a diverse array of in vitro cell-derived models of mammalian development
have been described that hold immense potential for exploring fundamental questions in …

How paracrine signals are interpreted to yield multiple cell fate decisions in a dynamic
context during human development in vivo and in vitro remains poorly understood. Here we …

During development, cell signaling instructs tissue patterning, the process by which initially
identical cells give rise to spatially organized structures consisting of different cell types …

Mapping morphogenesis and mechanics in embryo models | Nature Methods Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited …

In vitro human models, such as gastruloids and organoids, are complex three-dimensional
(3D) structures often consist of cells from multiple germ layers that possess some attributes …