Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial
diseases and have an important role in cardiac repair and remodelling, regulating the …

Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

Cardiovascular disease is the leading cause of death worldwide, both in the general
population and among patients with chronic kidney disease (CKD). In most cases, the …

Efferocytosis, the clearance of apoptotic cells (ACs) by macrophages, is critical for tissue
resolution, with defects driving many diseases. Mechanisms of efferocytosis-mediated …

Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is
largely based on genome-wide association study (GWAS) analysis of common SNPs …

Rationale: Atherosclerosis is a chronic inflammatory disease that is driven by the interplay of
pro-and anti-inflammatory leukocytes in the aorta. Yet, the phenotypic and transcriptional …

Endothelial to mesenchymal transition (EndMT) plays a major role during development, and
also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells …

Atherosclerosis is a progressive vascular disease triggered by interplay between abnormal
shear stress and endothelial lipid retention. A combination of these and, potentially, other …

Atherosclerosis is an inflammatory disease within the arterial wall that is responsible for
several important adverse vascular events, including coronary artery disease, myocardial …