Mucosal-associated invariant T cells for cancer immunotherapy

YR Li, K Zhou, M Wilson, A Kramer, Y Zhu, N Dawson… - Molecular Therapy, 2023 - cell.com
Human mucosal-associated invariant T (MAIT) cells are characterized by their expression of
an invariant TCR α chain Vα7. 2-Jα33/Jα20/Jα12 paired with a restricted TCR β chain. MAIT …

Reconstitution of T cell subsets following allogeneic hematopoietic cell transplantation

L Dekker, C de Koning, C Lindemans, S Nierkens - Cancers, 2020 - mdpi.com
Allogeneic (allo) hematopoietic cell transplantation (HCT) is the only curative treatment
option for patients suffering from chemotherapy-refractory or relapsed hematological …

MAIT and Vδ2 unconventional T cells are supported by a diverse intestinal microbiome and correlate with favorable patient outcome after allogeneic HCT

H Andrlová, O Miltiadous, AI Kousa, A Dai… - Science translational …, 2022 - science.org
Microbial diversity is associated with improved outcomes in recipients of allogeneic
hematopoietic cell transplantation (allo-HCT), but the mechanism underlying this …

Off-the-shelf allogeneic T cell therapies for cancer: opportunities and challenges using naturally occurring “universal” donor T cells

C Perez, I Gruber, C Arber - Frontiers in immunology, 2020 - frontiersin.org
Chimeric antigen receptor (CAR) engineered T cell therapies individually prepared for each
patient with autologous T cells have recently changed clinical practice in the management of …

The potential roles of mucosa-associated invariant T cells in the pathogenesis of gut graft-versus-host disease after hematopoietic stem cell transplantation

MG Gao, Y Hong, XY Zhao, XA Pan, YQ Sun… - Frontiers in …, 2021 - frontiersin.org
Gut acute graft-versus-host disease (aGVHD) is a serious complication after allogeneic
hematopoietic stem cell transplantation (allo-HSCT) and is associated with high mortality …

Antigen recognition by MR1-reactive T cells; MAIT cells, metabolites, and remaining mysteries

AJ Corbett, W Awad, H Wang, Z Chen - Frontiers in immunology, 2020 - frontiersin.org
Mucosal-associated Invariant T (MAIT) cells recognize vitamin B-based antigens presented
by the non-polymorphic MHC class I related-1 molecule (MR1). Both MAIT T cell receptors …

MAIT cells in barrier tissues: lessons from immediate neighbors

A Amini, D Pang, CP Hackstein… - Frontiers in …, 2020 - frontiersin.org
Mucosal-associated invariant T (MAIT) cells are innate-like T cells present at considerable
frequencies in human blood and barrier tissues, armed with an expanding array of effector …

MAIT cells and the microbiome

MF Jabeen, TSC Hinks - Frontiers in Immunology, 2023 - frontiersin.org
Mucosal associated invariant T (MAIT) cells are innate-like T lymphocytes, strikingly
enriched at mucosal surfaces and characterized by a semi-invariant αβ T cell receptor (TCR) …

Emerging role for MAIT cells in control of antimicrobial resistance

E Leeansyah, C Boulouis, ALH Kwa, JK Sandberg - Trends in Microbiology, 2021 - cell.com
Antimicrobial resistance is a serious threat to global public health as antibiotics are losing
effectiveness due to rapid development of resistance. The human immune system facilitates …

Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation

L Stern, HM McGuire, S Avdic… - Nature …, 2022 - nature.com
Human cytomegalovirus reactivation is a major opportunistic infection after allogeneic
haematopoietic stem cell transplantation and has a complex relationship with post …