The discovery of the gaseous molecule nitric oxide in 1987 unraveled investigations on its
functional role in the pathogenesis of a wide spectrum of biological and pathological …

Heme oxygenase 1 (HO-1) is induced in response to cellular stress and is responsible for
converting the prooxidant heme molecule into equimolar quantities of biliverdin (BV), carbon …

Is there any reason to write a third book on the topic of oxygen-ozone therapy? The first was
written four years ago for italian physicians, who, for some time, had complained about the …

This book represents the first serious attempt to explain the fundamental basis of
ozonetherapy and is a relevant step towards achieving further progress. Ozone is now …

This study investigated the role of heme oxygenase (HO)-1 in the cardiac tissue injury of
acute ischemia/reperfusion (I/R) in diabetic streptozotocin (STZ)-induced hyperglycemic rats …

The present review examines the role of the cytoprotective enzyme haeme oxygenase‐1
(HO‐1) in adaptive responses to inflammatory disease and explores strategies for its clinical …

Heme oxygenase (HO)-1 converts heme to bilirubin, carbon monoxide, and iron. Our prior
work has suggested a cardioprotective role for HO-1 in heart failure. To test whether HO-1 …

Bilirubin is the end product of heme catabolism by heme oxygenases. The inducible form of
these enzymes is heme oxygenase-1 (HO-1), which is the rate-limiting enzyme that can …

Hypoxia-inducible factor-1 (HIF-1) is a key regulator of the cellular hypoxic response. We
previously showed that HIF-1 activation is essential for heat acclimation (AC) in …

Aims: Inhibition of microRNA-92a (miR-92a) is reported to suppress endothelial
inflammation and delay atherogenesis. We hypothesize that miR-92a inhibition protects …