Combating implant infections: shifting focus from bacteria to host

S Amin Yavari, SM Castenmiller… - Advanced …, 2020 - Wiley Online Library
The widespread use of biomaterials to support or replace body parts is increasingly
threatened by the risk of implant‐associated infections. In the quest for finding novel anti …

TLR agonists as mediators of trained immunity: mechanistic insight and immunotherapeutic potential to combat infection

AM Owen, JB Fults, NK Patil, A Hernandez… - Frontiers in …, 2021 - frontiersin.org
Despite advances in critical care medicine, infection remains a significant problem that
continues to be complicated with the challenge of antibiotic resistance …

Immunomodulatory role of interferons in viral and bacterial infections

P Mertowska, K Smolak, S Mertowski… - International journal of …, 2023 - mdpi.com
Interferons are a group of immunomodulatory substances produced by the human immune
system in response to the presence of pathogens, especially during viral and bacterial …

MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages

AM Owen, L Luan, KR Burelbach, MA McBride… - Frontiers in …, 2022 - frontiersin.org
Immunocompromised populations are highly vulnerable to developing life-threatening
infections. Strategies to protect patients with weak immune responses are urgently needed …

Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres

EJ Curvino, EF Roe, H Freire Haddad… - Nature Biomedical …, 2023 - nature.com
Inflammatory bowel disease lacks a long-lasting and broadly effective therapy. Here, by
taking advantage of the anti-infection and anti-inflammatory properties of natural antibodies …

Epigenetic adjuvants: durable reprogramming of the innate immune system with adjuvants

A Lee, F Wimmers, B Pulendran - Current opinion in immunology, 2022 - Elsevier
Highlights•Studies suggest adjuvants could induce epigenetic reprogramming of myeloid
cells.•Reprogramming could lead to a durable state of heightened antiviral resistance.•This …

Platelet CXCL4 mediates neutrophil extracellular traps formation in ANCA-associated vasculitis

K Matsumoto, H Yasuoka, K Yoshimoto, K Suzuki… - Scientific reports, 2021 - nature.com
Neutrophils form neutrophil extracellular traps (NETs), which are involved in the
pathogenesis of ANCA-associated vasculitis (AAV). Recent reports suggest that platelets …

[HTML][HTML] Trained immunity-inducing vaccines: Harnessing innate memory for vaccine design and delivery

I Baydemir, E Dulfer, MG Netea, JD Andrés - Clinical Immunology, 2024 - Elsevier
While the efficacy of many current vaccines is well-established, various factors can diminish
their effectiveness, particularly in vulnerable groups. Amidst emerging pandemic threats …

Bacteria in cancer therapy: A new generation of weapons

JY Fan, Y Huang, Y Li, TA Muluh, SZ Fu… - Cancer …, 2022 - Wiley Online Library
Tumors are presently a major threat to human life and health. Malignant tumors are
conventionally treated through radiotherapy and chemotherapy. However, traditional …

Cell death proteins in sepsis: key players and modern therapeutic approaches

CS Yang, CM Coopersmith, JD Lyons - Frontiers in Immunology, 2024 - frontiersin.org
Cell death proteins play a central role in host immune signaling during sepsis. These
interconnected mechanisms trigger cell demise via apoptosis, necroptosis, and pyroptosis …