Blood transfusion is the most common procedure completed during a given hospitalization
in the United States. Although often life-saving, transfusions are not risk-free. One sequela …

Red blood cell (RBC) transfusions can be life‐sustaining in chronic inherited anaemias,
such as thalassaemia, and the indications for blood transfusions in patients with sickle cell …

Sickle cell disease (SCD) patients are at increased risk of red blood cell (RBC)
alloimmunization. Recipient inflammatory state at time of transfusion has been shown to …

Background: Development of alloantibodies against the foreign red blood cell (RBC)(
alloimmunization) is a well-known complication in thalassemia patients when performing …

Red blood cell (RBC) transfusions are a milestone in the treatment for sickle cell anaemia
(SSA) and for thalassaemia. RBC alloimmunization remains a major challenge of chronic …

BACKGROUND: Red blood cell (RBC) alloimmunization is a major problem in chronically
transfused patients because of the risk of hemolytic reactions and limited availability of …

Chronic transfusion therapy has played a central role in extending life expectancy for
patients with hemoglobinopathies such as thalassemia. However, this life-saving therapy is …

The development of hemolytic erythrocyte alloantibodies and autoantibodies complicates
transfusion therapy in thalassemia patients. These antibodies ultimately increase the need …

Background When problems with compatibility arise, transfusion services often use time-
consuming serological tests to identify antigen-negative red cell units for safe transfusion …

Background Chronic red blood cell transfusion is the first-line treatment for severe forms of
thalassaemia. This therapy is, however, hampered by a number of adverse effects, including …