Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …

The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

Menstruation occurs in few species and involves a cyclic process of proliferation, breakdown
and regeneration under the control of ovarian hormones. Knowledge of normal endometrial …

Aging is a complex biological process with multifactorial nature underlined by genetic,
environmental, and social factors. In the present paper, we review several mechanisms of …

Autophagy is an evolutionarily conserved process that plays a pivotal role in the
maintenance of cellular homeostasis and its impairment has been implicated in the …

Since the outbreak of Covid-19, several observational studies on diabetes and Covid-19
have reported a favourable association between metformin and Covid-19-related outcomes …

Aging is a natural process, characterized by progressive loss of physiological integrity,
impaired function, and increased vulnerability to death. For centuries, people have been …

Obesity is defined by the World Health Organization (WHO) as abnormal or excessive fat
accumulation that presents a health risk. Obesity has reached epidemic proportions, with …

Early since the onset of the COVID-19 pandemic, the medical and scientific community were
aware of extra respiratory actions of SARS-CoV-2 infection. Endothelitis, hypercoagulation …

This review examines the impact of obesity on the pathophysiology of heart failure with
preserved ejection fraction (HFpEF) and focuses on novel mechanisms for HFpEF …