Large DNA viruses defend against hostile assault executed by the host immune system by
producing an array of gene products that systematically sabotage key components of the …

Despite considerable advances in the understanding of the pathogenesis of meningococcal
disease, this infection remains a major cause of morbidity and mortality globally. The role of …

Differential scanning calorimetry (DSC) is an analytical technique that measures the molar
heat capacity of samples as a function of temperature. In the case of protein samples, DSC …

Protein kinase B (PKB/Akt) is a key regulator of cell growth, proliferation and metabolism. It
possesses an N-terminal pleckstrin homology (PH) domain that interacts with equal affinity …

Human complement factor H, consisting of 20 complement control protein (CCP) modules, is
an abundant plasma glycoprotein. It prevents C3b amplification on self surfaces bearing …

Factor H (FH) is a regulatory cofactor for the protease factor I in the breakdown of C3b in the
complement system of immune defence, and binds to heparin and other polyanionic …

Orthopoxviruses Pathogenic for Humans covers those viruses capable of causing disease in
man, including monkeypox, smallpox, cowpox, and vaccinia. The coverage of each virus is …

Membrane cofactor protein (MCP; CD46), a widely distributed regulator of complement
activation, is a cofactor for the factor I-mediated degradation of C3b and C4b deposited on …

In the past year, important advances have been made in the area of host-related
immunomodulatory genes encoded by the larger DNA viruses, particularly for the poxviruses …

In the course of evolution, viruses have developed various molecular mechanisms to evade
the defense reactions of the host organism. When understanding the mechanisms used by …