The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

Parkinson's disease (PD) is a neurodegenerative disease characterized by a progressive
loss of dopaminergic neurons from the nigrostriatal pathway, formation of Lewy bodies, and …

The endocannabinoids are lipid-derived messengers that play a diversity of regulatory roles
in mammalian physiology. Dysfunctions in their activity have been implicated in various …

In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic
cannabinoids have received growing interest as treatment options in neurodegenerative …

Glucocorticoids (GCs) are used in treating viral infections, acute spinal cord injury,
autoimmune diseases, and shock. Several patients develop GC‐induced osteonecrosis of …

The endocannabinoid system (ECS) exerts a modulatory effect of important functions such
as neurotransmission, glial activation, oxidative stress, or protein homeostasis …

Significance: Redox imbalance may lead to overproduction of reactive oxygen and nitrogen
species (ROS/RNS) and subsequent oxidative tissue damage, which is a critical event in the …

The GPR55 receptor is expressed abundantly in the brain, especially in the striatum,
suggesting it might fulfill a role in motor function. Indeed, motor behavior is impaired in mice …

Previous studies suggest that the endocannabinoid system plays an important role in the
neuropathological basis of Parkinson's disease (PD). This study was designed to detect …

Neuronal survival depends on the glia, that is, on the astroglial and microglial support.
Neurons die and microglia are activated not only in neurodegenerative diseases but also in …