Intervertebral disc (IVD) degeneration is a major contributing factor for discogenic low back
pain (LBP), causing a significant global disability. The IVD consists of an inner core …

Intervertebral disc degeneration is a common cause of discogenic low back pain resulting in
significant disability. Current conservative or surgical intervention treatments do not reverse …

Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …

The primary sensory system requires the integrated function of multiple cell types, although
its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 …

The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …

The original formulation of Gate Control Theory (GCT) proposed that the perception of pain
produced by spinal cord signaling to the brain depends on a balance of activity generated in …

Neurons in the spinal dorsal horn process sensory information, which is then transmitted to
several brain regions, including those responsible for pain perception. The dorsal horn …

Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold
mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report …

The incidence of chronic pain is estimated to be 20–25% worldwide. Few patients with
chronic pain obtain complete relief from the drugs that are currently available, and more than …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …